Dhaka Medical College, University of Dhaka, Bangladesh . (2004-2011)
M.Sc. in Biotechnology and Bio-engineering
Sungkyunkwan University, South Korea. (2013-2015)
Marks: 96.28%, CGPA: 4.19, CGPA Scale: 4.5,
Achievement: SKKU Global scholarship from 2013-2015
Thesis Title: Anti-inflammatory effect of naturally-occurring peptide mixture MTRP-1
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In this study, we evaluated the in vitro and in vivo immunomodulatory properties of naturally-occurring peptides MTRP-1. This peptide significantly inhibited LPS-induced nitric oxide (NO) production in RAW 264.7 cells. It also dose-dependently reduced mRNA expression of pro-inflammatory genes such as inducible NO synthase (iNOS), tumour necrosis factor (TNF)-α, and cyclooxygenase (COX-2). In addition, immunoblotting analysis shows that nuclear levels of transcription factors such as p65, p50, c-Fos, and c-Jun were reduced by MTRP-1 treatment. Moreover, MTRP-1 inhibited the activation of both NF-κB-regulatory upstream signalling enzymes including IκBα, AKT, p85, Syk, and Src, and AP-1-regulatory enzymes including TRAF6, TAK1, MKK4/7, MKK 3/6, and IRAK1/4. Finally, MTRP-1 clearly ameliorated the inflammatory symptoms in EtOH/HCl-induced gastritis and DSS-induced colitis mouse models. These data strongly suggest that MTRP-1 can be applied as a potential natural anti-inflammatory agent with Src/Syk/NF-κB and IRAK1/4/AP-1 inhibitory properties.
